Category: Microbiome

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Bioengineering Microbiome

Synthetic microbiome? Genetic engineering allows different species of ...

What if the bacteria that live in your gut could monitor your health, report disease, and produce beneficial molecules? Researchers have gotten one step closer to creating such a ‘synthetic microbiome’ by engineering different species of bacteria so they can talk to each other. Given that there are over 1,000 different strains of intestinal interlopers in the human gut, such coordination is crucial for the development of systems that can sense and improve human digestive health.

Metabolites Microbiome Nutrition

Druglike molecules produced by gut bacteria can affect gut immune ...

Stanford researchers found that manipulating the gut microbe Clostridium sporogenes changed levels of molecules in the bloodstreams of mice and, in turn, affected their health.

Here’s some food for thought: When you lick your Thanksgiving plate clean this week, you’re not just feeding yourself; you’re also providing meals to the trillions of microbes that live in your gut. And if your dinner includes turkey, a notoriously rich source of the amino acid tryptophan, the gut bacterium Clostridium sporogenes will have the job of breaking down that tryptophan. Then the molecules that are produced by the microbe will flow into your bloodstream in the same way a prescription drug might, interacting with your immune system and changing the biology of the intestines.

Stanford University School of Medicine researchers…